skip to main content

Weston Porter

Weston Porter
Weston Porter

Professor

Contact

Department of Veterinary Physiology & Pharmacology
TX
WPorter@cvm.tamu.edu
Google Scholar

Biography

Education

  • B.S., Texas A&M University, 1991
  • Ph.D., Texas A&M University, 1996

Focus Areas

  • Toxicology
  • Cell Biology
  • Environmental Health
  • Genetics
  • Oncology

Research Interests

  • My laboratory is interested in determining the role of factors in normal development and how disruption of these pathways results in associated pathologies.

Representative Publications

  • Porter W, Saville B, Hoivik D, Safe S (1997). Functional synergy between the transcription factor Sp1 and the estrogen receptor. MOL ENDOCRINOL. 11, 1569-80
  • Scribner KC, Wellberg EA, Metz RP, Porter WW (2011). Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NF?B. MOL ENDOCRINOL. 4, 635-44
  • Wellberg E, Metz RP, Parker C, Porter WW (2010). The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation. DEVELOPMENT. 6, 945-52
  • Gustafson TL, Wellberg E, Laffin B, Schilling L, Metz RP, Zahnow CA, Porter WW (2009). Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPbeta. ONCOGENE. 12, 1561-8
  • Boggs RM, Wright ZM, Stickney MJ, Porter WW, Murphy KE (2008). MicroRNA expression in canine mammary cancer. MAMM GENOME. 7-8, 561-9
  • Laffin B, Wellberg E, Kwak HI, Burghardt RC, Metz RP, Gustafson T, Schedin P, Porter WW (2008). Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. MOL CELL BIOL. 6, 1936-46
  • Higgins KJ, Liu S, Abdelrahim M, Vanderlaag K, Liu X, Porter W, Metz R, Safe S (2008). Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins. MOL ENDOCRINOL. 2, 388-402
  • Dash B, Afriyie-Gyawu E, Huebner HJ, Porter W, Wang JS, Jolly PE, Phillips TD (2007). Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. J TOXICOL ENVIRON HEALTH A. 1, 58-66
  • Dash B, Metz R, Huebner HJ, Porter W, Phillips TD (2007). Molecular characterization of two superoxide dismutases from Hydra vulgaris. GENE. 1-2, 93-108
  • Dash B, Metz R, Huebner HJ, Porter W, Phillips TD (2006). Molecular characterization of phospholipid hydroperoxide glutathione peroxidases from Hydra vulgaris. GENE. 381, 1-12
  • Kwak HI, Gustafson T, Metz RP, Laffin B, Schedin P, Porter WW (2007). Inhibition of breast cancer growth and invasion by single-minded 2s. CARCINOGENESIS. 2, 259-66
  • Dash B, Afriyie-Gyawu E, Huebner HJ, Porter W, Wang JS, Jolly PE, Phillips TD (2006). Noninvasive identification of interindividual variation in xenobiotic-metabolizing enzymes: implications for cancer epidemiology and biomarker studies. J TOXICOL ENVIRON HEALTH A. 13, 1203-16
  • Metz RP, Kwak HI, Gustafson T, Laffin B, Porter WW (2006). Differential transcriptional regulation by mouse single-minded 2s. J BIOL CHEM. 16, 10839-48
  • Metz RP, Qu X, Laffin B, Earnest D, Porter WW (2006). Circadian clock and cell cycle gene expression in mouse mammary epithelial cells and in the developing mouse mammary gland. DEV DYN. 1, 263-71
  • Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S (2001). Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. J MOL ENDOCRINOL. 1, 31-42
  • Duan R, Porter W, Samudio I, Vyhlidal C, Kladde M, Safe S (1999). Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. MOL ENDOCRINOL. 9, 1511-21
  • Safe S, Wang F, Porter W, Duan R, McDougal A (1998). Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. TOXICOL LETT. 102
  • Sun G, Porter W, Safe S (1998). Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. MOL ENDOCRINOL. 6, 882-90
  • Duan R, Porter W, Safe S (1998). Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. ENDOCRINOLOGY. 4, 1981-90
  • Wang F, Porter W, Xing W, Archer TK, Safe S (1997). Identification of a functional imperfect estrogen-responsive element in the 5'-promoter region of the human cathepsin D gene. BIOCHEMISTRY. 25, 7793-801
  • Wang WL, Porter W, Burghardt R, Safe SH (1997). Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin. CARCINOGENESIS. 5, 925-33
  • Porter W, Wang F, Wang W, Duan R, Safe S (1996). Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression. MOL ENDOCRINOL. 11, 1371-8
  • Wang WL, Thomsen JS, Porter W, Moore M, Safe S (1996). Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells. BR J CANCER. 3, 316-22
  • Krishnan V, Porter W, Santostefano M, Wang X, Safe S (1995). Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. MOL CELL BIOL. 12, 6710-9
  • Wang X, Porter W, Krishnan V, Narasimhan TR, Safe S (1993). Mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated decrease of the nuclear estrogen receptor in MCF-7 human breast cancer cells. MOL CELL ENDOCRINOL. 1-2, 159-66
  • Scribner KC, Wellberg EA, Metz RP, Porter WW (2011). Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NF?B. MOL ENDOCRINOL. 4, 635-44
  • Coster DJ, Lowe MT, Keane MC, Williams KA, Australian Corneal Graft Registry Contributors (2014). A comparison of lamellar and penetrating keratoplasty outcomes: a registry study. OPHTHALMOLOGY. 5, 979-87
  • Sarkar TR, Battula VL, Werden SJ, Vijay GV, Ramirez-Peña EQ, Taube JH, Chang JT, Miura N, Porter W, Sphyris N, Andreeff M, Mani SA (2014). GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer. ONCOGENE.
  • Vizzotto M, Porter W, Byrne D, Cisneros-Zevallos L (2014). Polyphenols of selected peach and plum genotypes reduce cell viability and inhibit proliferation of breast cancer cells while not affecting normal cells. FOOD CHEM. 164, 363-70

The Texas A&M Health Center of Excellence in Cancer Research is funded by a Texas Regional Excellence in Cancer (TREC) award from the Cancer Prevention and Research Institute of Texas (CPRIT).